Transition between epithelial mesenchymal states free
transition (EMT) is an indispensable mechanism during morphogenesis, as without mesenchymal cells, tissues and organs will never be formed. Transitions between epithelial and mesenchymal states have crucial roles in embryonic development and without EMT, in which polarized epithelial cells are Based on these studies, we propose that reversible transitions between mesenchymallike and epitheliallike stem cell states in a process regulated by the tumor microenvironment are necessary for these tumor cells to invade and form metastasis at distant sites.transition between epithelial mesenchymal states Breast cancer stem cells (BCSCs) are thought to mediate metastasis and resistance to radiation and chemotherapy. Here, Liu et al. show that BCSCs exist in distinct mesenchymallike (CD24CD44) and epitheliallike (ALDH) states with different proliferative and invasive capacities, suggesting it may be clinically important to target alternative CSC states.
Transitions between epithelial and mesenchymal states underlie epithelial cell plasticity and contribute to tumour progression and intratumoural heterogeneity. transition between epithelial mesenchymal states Epithelial and mesenchymal cells are two major types of cells and the transitions between these two cell states as transition (EMT) and transition Transitions between epithelial and mesenchymal states underlie epithelial cell plasticity and contribute to tumour progression and intratumoural heterogeneity. How can the answer be improved? transition. A transition ( MET) is a reversible biological process that involves the transition from motile, multipolar or spindleshaped mesenchymal cells to planar arrays of polarized cells called epithelia. MET is the reverse process of transition (EMT).Rating: 4.41 / Views: 757