Transition between epithelial mesenchymal states

2020-02-23 17:05

Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Owing to the importance of these tumourassociated phenotypes in metastasis and cancerrelated mortality, targeting the products of such cellular plasticity is an attractive but challenging approach that is likely to lead to improved clinical management of cancer patients.Epithelial and mesenchymal cells are two major types of cells and the transitions between these two cell states as transition (EMT) and transition (MET) have been observed during multiple cell fate conversions including embryonic development, tumor progression and somatic cell reprogramming. transition between epithelial mesenchymal states

The induction of an EMT, or introduction of the genes that cause an EMT, prompt cancer cells to become more aggressive and spread, as well as to acquire a stemlike state and become resistant to common therapies. 4 This provides a link between the ability of a cell to convert between epithelial and mesenchymal states and the ability of a cell

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transition (EMT) is an indispensable mechanism during morphogenesis, as without mesenchymal cells, tissues and organs will never be formed. Transitions between epithelial and mesenchymal states have crucial roles in embryonic development and without EMT, in which polarized epithelial cells are Based on these studies, we propose that reversible transitions between mesenchymallike and epitheliallike stem cell states in a process regulated by the tumor microenvironment are necessary for these tumor cells to invade and form metastasis at distant sites.transition between epithelial mesenchymal states Breast cancer stem cells (BCSCs) are thought to mediate metastasis and resistance to radiation and chemotherapy. Here, Liu et al. show that BCSCs exist in distinct mesenchymallike (CD24CD44) and epitheliallike (ALDH) states with different proliferative and invasive capacities, suggesting it may be clinically important to target alternative CSC states.

Transitions between epithelial and mesenchymal states underlie epithelial cell plasticity and contribute to tumour progression and intratumoural heterogeneity. transition between epithelial mesenchymal states Epithelial and mesenchymal cells are two major types of cells and the transitions between these two cell states as transition (EMT) and transition Transitions between epithelial and mesenchymal states underlie epithelial cell plasticity and contribute to tumour progression and intratumoural heterogeneity. How can the answer be improved? transition. A transition ( MET) is a reversible biological process that involves the transition from motile, multipolar or spindleshaped mesenchymal cells to planar arrays of polarized cells called epithelia. MET is the reverse process of transition (EMT).

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